Wir stehen für den Transfer von Wissenschaft in die Praxis

Die ChondroFiller® Produkte wurden in enger Zusammenarbeit unseres Teams mit Wissenschaftlern und Forschern des Fraunhofer-Instituts für Grenzflächen- und Bioverfahrenstechnik IGB in Stuttgart entwickelt. meidrix biomedicals hat daraus Produkte für die orthopädische Praxis gemacht. Und an dieser Stelle schließt sich die Klammer, denn selbstverständlich wurde und wird der Einsatz des ChondroFiller® in klinischen Studien unabhängig untersucht.

Forschung und Entwicklung

Eine Übersicht über die Studien erhalten Sie nachfolgend:

2016 | Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.

Rothdiener, M., Hegemann, M., Uynuk-Ool, T., Walters, B., Papugy, P., Nguyen, P., Claus, V., Seeger, T., Stoeckle, U., Boehme, K. A., Aicher, W. K., Stegemann, J. P., Hart, M. L., Kurz, B., Klein, G., & Rolauffs, B. (2016). Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition. Scientific reports, 6, 35840.

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2017 | Mechanobiological processes of tissue engineered cartilage replacement materials.

Nachtsheim, J., Markert, B. and Stoffel, M. (2017), Mechanobiological processes of tissue engineered cartilage replacement materials. Proc. Appl. Math. Mech., 17: 211-212.

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2017 | The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces.

Uynuk-Ool, T., Rothdiener, M., Walters, B., Hegemann, M., Palm, J., Nguyen, P., Seeger, T., Stöckle, U., Stegemann, J. P., Aicher, W. K., Kurz, B., Hart, M. L., Klein, G., & Rolauffs, B. (2017). The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces. Journal of tissue engineering and regenerative medicine, 11(12), 3508–3522.

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2017 | Engineering the geometrical shape of mesenchymal stromal cells through defined cyclic stretch regimens.

Walters, B., Uynuk-Ool, T., Rothdiener, M., Palm, J., Hart, M. L., Stegemann, J. P., & Rolauffs, B. (2017). Engineering the geometrical shape of mesenchymal stromal cells through defined cyclic stretch regimens. Scientific reports, 7(1), 6640.

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2018 | Chondrocyte migration in an acellular tissue‐engineered cartilage substitute.

Nachtsheim, J., Dursun, G., Markert, B. and Stoffel, M. (2018), Chondrocyte migration in an acellular tissue‐engineered cartilage substitute. Proc. Appl. Math. Mech., 18: e201800425.

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2019 | Experimental Study on Cell-free Approach for Articular Cartilage Treatment, Current Directions in Biomedical Engineering.

Dursun, G., Markert, B., & Stoffel, M. (2019). Experimental Study on Cell-free Approach for Articular Cartilage Treatment, Current Directions in Biomedical Engineering, 5(1), 171-174.

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2019 | Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair.

Krüger, K., Schmid, S., Paulsen, F., Ignatius, A., Klinger, P., Hotfiel, T., Swoboda, B., & Gelse, K. (2019). Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair. International journal of molecular sciences, 20(17), 4277.

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2019 | Chondrocyte colonisation of a tissue-engineered cartilage substitute under a mechanical stimulus.

Chondrocyte colonisation of a tissue-engineered cartilage substitute under a mechanical stimulus.

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