We stand for the transfer of knowledge from science into practice
Our collagen products were developed in close cooperation between our team and scientists, doctors and researchers at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart. meidrix biomedicals has turned this into products for orthopaedic practice. The use of our collagen and ChondroFiller® liquid is and has been independently investigated in scientific and clinical studies.
Research and development
We are extremely happy to share our decades of experience in biomaterials and regenerative medicine with cooperation partners from clinical, university and industry sectors for innovative research and development projects in a far-reaching network.
Current studies
on ChondroFiller®
liquid
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healthcare professionals
An overview of some scientific studies on ChondroFiller® liquid can be found here:
2016 | Retrospective study of cell-free collagen matrix for cartilage repair
Breil-Wirth A., von Engelhardt LV, Lobner S, Jerosch J: Retrospektive Untersuchung einer zellfreien Matrix zur Knorpeltherapie. OUP 2016; 9: 515-520 DOI 10.3238/oup.2016.0515-0520
2018 | Knorpelinduktion mittels zellfreier Kollagenmatrix (Chondrofiller liquid)
Beck OT: Knorpelinduktion mittels zellfreier Kollagenmatrix (Chondrofiller
liquid). Klinische und MRT-kontrollierte Nachuntersuchung.
OUP 2018; 7: 620–624 DOI 10.3238/oup.2018.0620–0624
2020 | Mid-term results of regeneration of articular cartilage defects using cell-free collagen matrix (ChondroFiller Liquid)
Jerosch J, Joseph P. OUP 2020; 9: 109–115 DOI 10.3238/oup.2019.0109–0115
2021 | Hip Chondral Defects: Arthroscopic Treatment With the Needle and Curette Technique and ChondroFiller
Luis Perez-Carro, Paola Rosi Mendoza Alejo, Gustavo Gutierrez Castanedo, Guillermo Menendez Solana, Jose Antonio Fernandez Divar, Pablo Galindo Rubin,
Ana Alfonso Fernandez. Arthrosc Tech 2021 Jun 20;10(7):e1669-e1675.
2021 | Acellular Matrix-Induced Chondrogenesis Technique Improves the Results of Chondral Lesions Associated with Femoroacetabular Impingement
José Carlos De Lucas Villarrubia, Miguel Ángel Méndez Alonso, Marta Isabel Sanz Pérez, Fernando Trell Lesmes, Alberto Panadero Tapia. Arthroscopy Techniques, Vol 10, No 7 (July), 2021: pp e1669-e1675
2023 | Meniscus Implantation and Cartilage Induction.
Beck OT. VideoACCART Journal 1 (2023)
2023 | The Use of an Acellular Collagen Matrix ChondroFiller® Liquid for Trapeziometacarpal Osteoarthritis
Corain M., Zanotti F., Giardini M., Gasperotti L., Invernizzi E., Biasi V., Lavagnolo U. Journal of Arthritis 2023, Vol. 12, Issue 01, 001-005
2024 | Implantation of ChondroFiller liquid as scaffold material for treatmant of chondral lesion of the knee joint
Simeonov E., J of IMAB. 2024 Oct-Dec;30(4)
2025 | Chondrofiller and Treatment of Cartilage Defects in the Knee
Syed R., Rachha R., Thati S. Acta Scientific Orthopaedics 7.10 (2024): 03-07
2025 | Arthroscopic Collagenous Matrix Therapy for Osteochondral Lesions of the Talus
Khan PS., Meleppuram J., Ahamed H, Nizaj N., Nair A., Ananthakrishnan R., Sreehari C.
Technical Note
https://doi.org/10.1016/j.eats.2025.103575
An overview of scientific publications on collagen can be found here:
2016 | Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.
Rothdiener, M., Hegemann, M., Uynuk-Ool, T., Walters, B., Papugy, P., Nguyen, P., Claus, V., Seeger, T., Stoeckle, U., Boehme, K. A., Aicher, W. K., Stegemann, J. P., Hart, M. L., Kurz, B., Klein, G., & Rolauffs, B. (2016). Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition. Scientific reports, 6, 35840.
2017 | Mechanobiological processes of tissue engineered cartilage replacement materials.
Nachtsheim, J., Markert, B. and Stoffel, M. (2017). Proc. Appl. Math. Mech., 17: 211-212.
2017 | The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces.
Uynuk-Ool, T., Rothdiener, M., Walters, B., Hegemann, M., Palm, J., Nguyen, P., Seeger, T., Stöckle, U., Stegemann, J. P., Aicher, W. K., Kurz, B., Hart, M. L., Klein, G., & Rolauffs, B. (2017). The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces. Journal of tissue engineering and regenerative medicine, 11(12), 3508–3522.
2017 | Engineering the geometrical shape of mesenchymal stromal cells through defined cyclic stretch regimens.
Walters, B., Uynuk-Ool, T., Rothdiener, M., Palm, J., Hart, M. L., Stegemann, J. P., & Rolauffs, B. (2017). Engineering the geometrical shape of mesenchymal stromal cells through defined cyclic stretch regimens. Scientific reports, 7(1), 6640.
2018 | Chondrocyte migration in an acellular tissue‐engineered cartilage substitute.
Nachtsheim, J., Dursun, G., Markert, B. and Stoffel, M. (2018). Proc. Appl. Math. Mech., 18: e201800425.
2019 | Experimental Study on Cell-free Approach for Articular Cartilage Treatment
Dursun, G., Markert, B., & Stoffel, M. Current Directions in Biomedical Engineering 2019;5(1):171–174
2019 | Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair.
Krüger, K., Schmid, S., Paulsen, F., Ignatius, A., Klinger, P., Hotfiel, T., Swoboda, B., & Gelse, K. (2019). Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair. International journal of molecular sciences, 20(17), 4277.
2019 | Chondrocyte colonisation of a tissue-engineered cartilage substitute under a mechanical stimulus.
Nachtsheim J., Dursun G., Markert B., Stoffel M. (2019). Medical Engineering & Physics, Volume 74
2020 | Compression Bioreactor-Based Mechanical Loading Induces Mobilization of Human Bone Marrow-Derived Mesenchymal Stromal Cells into Collagen Scaffolds In Vitro
Gamez C., Schneider-Wald B, Bieback K., Schuette A, Büttner S., Hafner M., Gretz N., Schwarz M. (2020). Int. J. Mol. Sci. 2020, 21, 8249
2020 | Complex mechanical behavior of human articular cartilage and hydrogels for cartilage repair
2022 | Swelling and Mechanical Characterization of Polyelectrolyte Hydrogels as Potential Synthetic Cartilage Substitute Materials
Romischke J., Scherkus A., Saemann M., Krueger S., Bader R., Kragl U., Meyer J. (2022). Gels 2022 May 12;8(5):296.
Research cooperations
Innovation network Reg4Bone
The aim of the network is to develop innovative technologies for bone regeneration.
meidrix biomedicals GmbH is a network partner in the Reg4Bone innovation network. Innovative materials to promote bone healing are becoming increasingly important in regenerative medicine. Particularly larger bone defects caused by trauma, tumor resection and infection, for example, exceed the bone’s own regenerative capabilities and are dependent on major clinical interventions. A highly innovative solution to this global public health problem is the development and application of novel bioresorbable materials, alternative scaffold structures, the design of new surface functionalizations and the use of cell therapy to support the bone’s own regeneration. With this international ZIM innovation network “Innovative Technologies for Bone Regeneration” and various partners from industry and research, these different approaches are to be taken up in order to develop innovative solutions to support bone regeneration.
Facts about the project and further links:
- Network partner: EurA AG www.eura-ag.com
- Program: Zentrales Innovationsprogramm Mittelstand (ZIM) www.zim.de
- Sponsored by: Bundesministeriums für Wirtschaft und Klimaschutz www.bmwk.de
ProMatLeben – joint project
Research into an industrial laser-based nano 3D printing technique for hierarchically structured cartilage bone implants on a polymer basis (Poly-IMPLANT-Print)
meidrix biomedicals GmbH was a partner in the joint project Poly-IMPLANT-Druck as part of the ProMatLeben – Polymere program of the BMBF (Federal Ministry of Education and Research).
The aim of the joint project Poly-IMPLANT-Druck was to develop biphasic carrier structures based on biocompatible polymers for the optimal treatment of bone-cartilage defects.
Conclusion
The Poly-IMPLANT printing project successfully demonstrated the feasibility of laser-based 3D printing for biologically and mechanically optimized bone-cartilage implants in joint-preserving orthopaedics. The materials developed showed high biocompatibility and stability as well as very good integration, which makes them promising for clinical use. In addition to optimization, future work could focus on clinical validation, approval and commercialization.
Facts about the project and further links:
- Duration: 01.05.2019 – 30.04.2022
- Project sponsor: VDI Projekt GmbH www.vditz.de
- Sponsored by: Bundesministerium für Bildung und Forschung (BMBF) www.bmbf.de
ZIM-Kooperationsprojekt
Development of a collagen fibre-reinforced and biphasic implant for cartilage regeneration
meidrix biomedicals GmbH and the Institute of Textile Machinery and High Performance Material Technology (ITM) at Dresden University of Technology are partners in a cooperation project as part of ZIM, the innovation programme for small and medium-sized enterprises run by the Germany Federal Ministry for Economic Affairs and Energy.
The goal of the ZIM cooperation project is to develop innovative functional and biphasic collagen fibre implants for joint cartilage regeneration.
The objective of the project is the development of a cell-free and absorbable implant reinforced with functionalised collagen fibres for cartilage regeneration in the knee. This biphasic implant with a layered structure is to consist of two parts: one part facing the bone and one part facing the cartilage. Both parts consist of a collagen gel reinforced with collagen fibres, whereby the wet-spun collagen fibres are functionalised in different ways depending on the layer. Both the functionalisation and the biphasic layout of the implant are strictly based on the layout of natural cartilage and the boundary surface between bone and cartilage.
The biphasic structuring of the implant is intended to achieve a significant improvement of cartilage regeneration, while the fibre reinforcement achieves higher strength and resilience in comparison to previously available products.
Facts about the project and further links:
- Duration: 01-Mar-2019 – 28-Feb-2021
- Project partners: Dresden University of Technology, Institute of Textile Machinery and High Performance Material Technology (ITM), contact person: Dr.-Ing. Dilbar Aibibu, Robert Tonndorf
- Programme: ZIM (German state innovation programme for small and medium-sized enterprises) www.zim.de
- Lead project partner: AiF Projekt GmbH www.aif-projekt-gmbh.de
- Sponsored by: German Federal Ministry for Economic Affairs and Energy (BMWi) www.bmwi.de
Further partners
Fraunhofer Institut
für Grenzflächen- und Bioverfahrenstechnik
www.igb.fraunhofer.de
BBF Sterilisationsservice GmbH
BioRegio STERN Management GmbH
